Comprehensive Review on Detection and Classification of Power Quality Disturbances in Utility Grid With Renewable Energy Penetration

The global concern with power quality is increasing due to the penetration of renewable energy (RE) sources to cater the energy demands and meet de-carbonization targets. Power quality (PQ) disturbances are found to be more predominant with RE penetration due to the variable outputs and interfacing converters. There is a need to recognize and mitigate PQ disturbances to supply clean power to the consumer. This article presents a critical review of techniques used for detection and classification PQ disturbances in the utility grid with renewable energy penetration. The broad perspective of this review paper is to provide various concepts utilized for extraction of the features to detect and classify the PQ disturbances even in the noisy environment. More than 220 research publications have been critically reviewed, classified and listed for quick reference of the engineers, scientists and academicians working in the power quality area

Shape control of composite plates with piezoelectric actuators

In this paper, shape control of composite plates using piezoelectric actuators is being investigated. The goal of this study was to see how composite plates behave when they are integrated with piezoelectric actuators. Modelling and simulation were done using COMSOL Multiphysics software and results were validated using previously published studies. Parametric investigations were carried out to inves-tigate the effect of patch locations and stacking sequences with respect to suppression of deflection. The obtained results showed that for uniformly distributed load considered in this work the patches worked effectively when they were placed at the center of the composite plate

IN SILICO ANALYSIS OF STRUCTURAL REQUIREMENTS FOR THIOPHENE DERIVATIVES AGAINST POLO LIKE KINASE-1 (PLK1)

Objective: Development of anti-mitotic drugs for chemotherapy of cancer has been one of the main focuses of research in 21st century. Present work aims to study the structural requirements of thiophene derivatives against PLK1 as a target for designing novel strategies for cancer chemoprevention. To understand the structural requirements that will lead to enhanced inhibitory potencies, we have carried out 3D-QSAR (quantitative structure-activity relationship) studies on a series of thiophene derivatives as PLK1 receptor inhibitors.Methods: CoMFA, CoMSIA and molecular docking studies were performed on a series of thiophene derivatives as PLK1 receptor inhibitors using Sybyl 6.7.Results: We have successfully derived statistically significant model from 100 thiophene derivatives and validated, it against an external test set of 34 compounds and 66 molecules used in the training set. The CoMFA model yielded q2-0.845, r2-0.978. While the CoMSIA model yielded q2-0.804, r2-0.968. The predictive ability of these models supported by docking studies; produced better docking scores and binding affinity to the specified target polo like kinase1 (3THB) and moreover, the 3D QSAR model used for suggesting the next-generation lead analogues.Conclusion: 3D-QSAR has been established for a series of Polo like Kinase1 (PLK1) inhibitors employing the most widely used techniques CoMFA and CoMSIA. The conclusions derived from both models are similar and reliable. Docking studies are also performed to obtain the bioactive confirmations for the whole data-set. The obtained 3D contour maps along with the docking results provided a rational clue for the design of more favorable anti-mitotic agents. Overall, the structural modifications of the lead molecule have achieved to improve selective PLK1 inhibitory activity.Â

IMPACT OF COVID-19 ON MULTIPLE BODY ORGAN FAILURE: A REVIEW

COVID-19 is a highly contagious disease caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2); which is a novel single-stranded positive RNA infection which consist of cytokines that activate the pathogenic systems that cause high respiratory pain condition, and adversely affect on multiple body organ in humans as per their immunity standards to fight against the virus. SARS-CoV-2 enters the host cell through Angiotensin-Converting Enzyme 2 (ACE 2). ACE 2 is a sub-part of the Renin-Aldosterone Angiotensin System (RAAS), intelligently communicated in the body's kidney, heart, lungs, and malignant tissues. The malfunctioning of RAAS in the body leads to hypertension, cardiovascular sicknesses, endocrine system and negatively affects a brain-body communication channel. Treatments on the RAAS structure, 'thiazolidinedione's and smoking, toxemia, kidney, lungs disorder due to the SARS-CoV-2 attack on the host cell and notice the behavioral changes of body organs the arrival of cytokines that causes multi-organ damage. This paper involves the study of the effects of coronavirus disease on multiple body-organ injuries

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124. Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98). Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial

Towards value generating capabilities for collaborative intermediary organisations

This study explores the capabilities of collaborative intermediary organisations (CIOs) and its value generating potential at the city scale. As an emerging organisational form, CIOs create public interest value by creating specific platforms for deliberations and collaboration between diverse stakeholders. This study is important in light of growing and divisive economic and social disparities. Effective solutions to complex problems require legitimate collaborative platforms aimed at creating public interest value. CIOs are one such platform. This study first explores the Johannesburg inner city context to understand the potential and design implications for CIOs. It furthermore identifies CIO capabilities and explores the question of how CIOs create value. Sixteen interviews with CIO leaders, experts and sector representatives from business, government and the community involved with CIOs were conducted. Semi-structured interviews were used to gather qualitative data which was analysed through content analysis. The research findings suggest that despite a challenging partnership context, through particular design considerations and relevant organisational capabilities, CIOs are a useful and noteworthy enabler for public interest value creation. The identified capabilities are collaborative leadership, the ability to build trust in action, supporting weaker sector to fulfill mandates, sound analytical skills as well as distinctive attributes which emphasise a commitment to the long term. CIOs create value directly by convening partners, providing a neutral platform and a ‘translation’ service, as well as through creatively leveraging diverse perspectives. The findings further show that leadership and mutual interest between sectors are the primary sources of CIO value. The value is realised through interaction between the respective partners which provides a host of intangible benefits. The study furthermore shows the potential of capable CIOs to activate further collaborative value.Dissertation (MBA)--University of Pretoria, 2014.zkgibs2015Gordon Institute of Business Science (GIBS)MBAUnrestricte

Identification of Novel and Potent Inhibitors Against Inha Reductase of Mycobacterium Tuberculosis Through a Ligand-based Virtual Screening Approach Identification of Novel and Potent Inhibitors Against Inha Reductase of Mycobacterium Tuberculosis Through

ABSTRACT InhA, the enoyl reductase from Mycobacterium tuberculosis and a member of the short-chain dehydrogenase/reductase (SDR) family, catalyzes the NADH-dependent reduction of long chain trans-2-enoyl-ACP fatty acids in the type II fatty acid biosynthesis pathway of M. tuberculosis. In the current study, we have generated shape and rocs based query for highly active compounds of INHA (oxopyrrolidine derivative), which is complexed with (PDB: 2H7M). Generated query was validated for goodness of hits and the predictive power of the query was determined. This query was further used for virtual screening. The top 10% screening hits were analyzed and docked. Based on the protein ligand interactions few final hits were selected for enzymatic screening studies

3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R)-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models

Objective: Monocyte chemo attractant protein-1 (MCP-1) is a member of the CC-chemokine family and it selectively recruits leukocytes from the circulation to the site of inflammation through binding with the chemotactic cytokine receptor 2B (CCR2B). The recruitment and activation of selected populations of leukocytes is a key feature in a variety of inflammatory conditions. Thus MCP-1 receptor antagonist represents an attractive target for drug discovery. To understand the structural requirements that will lead to enhanced inhibitory potencies, we have carried out 3D-QSAR (quantitative structure-activity relationship) studies on (R)-3-aminopyrrolidine series of molecules as CCR2B receptor antagonists. Materials and Methods: Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on a series of (R)-3-aminopyrrolidine derivatives as antagonists of CCR2B receptor with Sybyl 6.7v. Results: We have derived statistically significant model from 37 molecules and validated it against an external test set of 13 compounds. The CoMFA model yielded a leave one out r 2 (r 2 loo ) of 0.847, non-cross-validated r 2 (r 2 ncv ) of 0.977, F value of 267.930, and bootstrapped r 2 (r 2 bs ) of 0.988. We have derived the standard error of prediction value of 0.367, standard error of estimate 0.141, and a reliable external predictivity, with a predictive r 2 (r 2 pred ) of 0.673. While the CoMSIA model yielded an r 2 loo of 0.719, r 2 ncv of 0.964,F value of 135.666, r 2 bs of 0.975, standard error of prediction of 0.512, standard error of estimate of 0.180, and an external predictivity with an r 2 pred of 0.611. These validation tests not only revealed the robustness of the models but also demonstrated that for our models r 2 pred, based on the mean activity of test set compounds can accurately estimate external predictivity. Conclusion: The QSAR model gave satisfactory statistical results in terms of q 2 and r 2 values. We analyzed the contour maps obtained, to study the activity trends of the molecules. We have tried to demonstrate structural features of compounds to account for the activity in terms of positively contributing physicochemical properties such as steric, electrostatic, hydrophobic, hydrogen bond donor, and acceptor fields. These contour plots identified several key features, which explain the wide range of activities. The results obtained from models offer important structural insight into designing novel CCR2B antagonists before their synthesis